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Description

AB-PINACA?

buy AB-PINACA, and the latter is
being used as a synthetic cannabinoid in so-called ‘Spice’ mixtures, intended to
mimic the psychoactive effects of cannabis, it seems plausible that buy AB-PINACA is
also used as a legal alternative to herbal cannabis.

description ?

buy AB-PINACA (N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-1-pentyl-1H-indazole-3-carboxamide),
originally developed by Pfizer Inc. as a synthetic cannabinoid receptor agonist (SCRA), has been
encountered outside medical settings as a synthetic constituent and found in herbal smoking
mixtures that are sold under a variety of brand names. It is common for retailers to purchase bulk
quantities of the synthetic substance and add the synthetic material to plant matter that is then
distributed onto the market. However,  buy AB-PINACA is also available in powdered form as a
“research chemical”.

buy AB-PINACA online cheap
buy AB-PINACA online cheap

Stereoisomers

The synthesis procedures described in the original patent literature
place an
emphasis on the preparation of the (S)-enantiomer based on the use of L-valinamide
in the last reaction step (see below). However, it is currently not known whether
buy AB-PINACA has been exclusively found on the market with the absolute (S)-
configuration although it appears very likely to be the case.

Methods and Ease of Illicit Manufacturing

The preparation of buy AB-PINACA is straightforward and follows standard procedures
that start with indazole-3-carboxylic acid (1), which can also be prepared if not
available as the starting material. Esterification (2) and N
1
alkylation  followed
by saponification provides access to the carboxylic acid precursor  that is then
coupled with L-valinamide to give the (S)-enantiomer of AB-PINACA . It was
also observed that the alkylation reaction resulted in the formation of the N
2
alkylated regioisomer as an impurity, which was then shown to result in very low
potency as CB1 and CB2 receptor agonists.

Chemical Properties

Melting point: 121.8 °C (base).
Boiling point: Information could not be identified.
Solubility: Information could not be identified.buy  AB-PINACA is expected to be
lipophilic in nature and therefore soluble in organic solvents.

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